Primitive Collagen. Softer skin, anti-wrinkle, less joint pain in 30 days
Collagen can keep osteoporosis away, detoxify your intestine, help you sleep, improve your skin, remove your joint pain, maintain your lean muscle mass and many other precious health/sport benefits
Keep on reading to learn all the reasons why you should take collagen!
Do you remember Simmenthal canned meat?
The meat was wrapped in a semi-transparent substance, gelatine, which was very good!
Gelatine comes from collagen, the most abundant protein in humans and animals (about 25% of the total protein mass), representing about 6% of body weight in humans.
Once cooked, the collagen decomposition into gelatine is irreversible; its long protein fibers, or tiny fibers, are broken down into small compounds of amino acids.
However, the chemical composition of gelatin is very similar to its mother molecule.
Collagen is found almost everywhere in the body, but is more abundant in the skin, bones, tendons and ligaments.
It holds our tissues together, providing the skeleton with a robust but flexible structure and some types of collagen fibrils are, gram for gram, stronger than steel. (1)
Collagen in the skin, bones, ligaments and tendons of animals, increases the reserves of human collagen, which leads to significant health benefits below.
It is made almost entirely of protein (98 to 99%).
Collagen is rich in vital amino acids, although it does not contain all the essential amino acids, making it an incomplete protein.
The amino acids that it is provided though are particularly important for health, in particular glycine, but also other fundamental amino acids such as Proline, Glutamic acid and Lysine. (2)
Collagen is Paleo!
Our hunter-gatherer ancestors ate much more collagen than we do today.
This is because they widely used nose-to-tail consumption, they used to cook and consume the entire animal, including skin, tendons and other gelatinous elements.
We have lost the practice of consuming whole animals and gelatin-rich cuts are generally discarded, or at least underestimated, now. (Some, such as beef shank or roast, are also considered "hard" and therefore less attractive than softer and more expensive ones.)
Furthermore, vegetarians do not eat many (or none) of animal products.
This means that we are taking a lot less collagen than our ancestors, if not at all.
10 (+1) reasons to take collagen ... Now!
Since we usually do not use the entire animal, or in some cases completely avoid the meat, we lose the many benefits of this unique food.
1. Increases skin elasticity
Collagen is one of the primary structural elements of the skin.
As we age, we naturally lose collagen, our skin goes limp and wrinkles come.
Collagen provides glycine and proline, key elements that can help your body create enough of this important protein to improve the health and appearance of your skin.
In particular, several studies have shown an improvement in skin elasticity and hydration, as well as a reduction in deep wrinkles, with the integration of collagen hydrolyzate. (3,4)
A diet rich in collagen can also protect against the effects of aging sunlight, preventing wrinkles in the future. (5)
Collagen also seems to induce hair growth and lead to thicker and fuller locks. (6,7)
2. Reduces cellulite and stretch marks
There is no doubt that our genetics play an enormous role in the onset of cellulite and stretch marks, but the levels of collagen in our body contribute to the appearance of our skin.
With the daily intake of collagen, we make sure that the levels of this substance do not decrease drastically and therefore a healthy level is maintained.
The skin consequently will have a structure that will be less prone to collapse and lead to cellulite.
3. It manages inflammation
Chronic inflammation is known to be the main cause of many health problems.
However, some research has shown that Glycine, an amino acid found in collagen supplements (such as "Primitive Collagen"), is a great tool to reduce inflammation.
4. Improves sleep quality
For every human being, sleep is crucial for its metabolic function, physics and mental health.
Gelatin can help to combine sleep due to its abundance of glycine.
Only a few tablespoons can provide about three grams of glycine, enough to cause measurable improvements in sleep quality. (8,9)
Glycine is also an inhibitory neurotransmitter, which means that it can reduce anxiety and promote mental calm to make you sleep through the night. (10)
5. Improves the states of anxiety
Everyone feels anxious once in a while, some more than others.
Chronic anxiety and stress can seriously affect our daily lives.
But glycine is also an inhibitory neurotransmitter, which means that it is a natural way to calm the brain and create balance.
6. Decreases joint pain
The bone lives, the tissue grows and mainly includes collagen and, as already mentioned, this substance is the glue that holds our tissues together.
So, it's easy to see why getting more collagen is good for bone and joint health.
Research shows that gelatine can have a beneficial effect on cartilage metabolism and inhibit collagen breakdown in bones. It can be effective in the treatment of osteoporosis and osteoarthritis. (11,12,13)
Its amino acids glycine and proline are anti-inflammatory and are probably responsible for research findings that find gelatin effective in reducing joint pain associated with arthritis.
Lysine strengthens bones by helping the body absorb calcium and form collagen.
The body cannot produce this amino acid, so it must come from the diet.
Lysine has also been shown in animal studies to accelerate fracture healing. (14)
7. Appetite control
If you are trying to lose weight, collagen is an excellent option because being like a protein, it makes you feel fuller longer regardless of the time of intake.
8. Improves digestion
Intestinal permeability (very common for people with certain lifestyles, such as eating cereals, dairy products, legumes, alcohol, etc.) can lead to physical and mental health problems, nutritional deficiencies and anxiety.
Thanks to the amino acids glycine, proline and glutamine, collagen can improve intestinal integrity and digestive strength, improving gastric acid secretion and restoring a healthy lining in the stomach. (15,16)
Collagen also absorbs water and helps keep the digestive tract fluid, promoting good intestinal transit and healthy bowel movements. (17)
Soups, broths rich in gelatin or supplements such as "Primitive Collagen" are key components to improve bowel function and promote healthy digestion.
9. Increase energy levels
You can take collagen to increase metabolism and energy levels due to its glycine content.
You can jump instead of crawling out of bed every day!
10. Longer hair and healthier nails
Collagen is a central component of hair and nails and therefore having healthy levels of this substance in your body ensures healthy, long, sensual, brighter and stronger hair.
Even your nails get longer and stronger because they won't break more easily.
Collagen is an excellent ingredient that will ensure you live a longer and healthier life, with strong bones, longer and shinier hair, better nails and glowing skin.
11. Maintains muscle mass
Glycine is the hero here again: research has found that increasing the intake of glycine, through supplementation or foods high in glycine such as gelatin, can help slow or reduce the loss of bound muscle at the age.
This weakness can make some people less physically active as they get older, and can even increase the risk of falling due to reduced strength and stability or getting hurt when they train.
Additional glycine can protect muscles in a variety of wasting conditions caused by serious illnesses such as cancer or very low calorie intake. (18,19)
The List of the Collagen benefits continues!
Research suggests that gelatin can also help in weight loss, helps control blood sugar, decreases inflammation in type 2 diabetics, improves cognitive / mental health and much more. (20,21,22,23)
Are you a vegetarian? A warning ...
Vegetarians often have low levels of glycine.
Vegetarians and vegans do not consume as much glycine as meat eaters and we have seen how important this component of collagen is to health.
Studies have shown that vegetarians and vegans have significantly higher levels of homocysteine, on average, than omnivores, putting them at significant risk of cardiovascular problems, ie exactly the opposite of what they wanted to achieve by removing meat. (25)
This is probably due to nutritional deficiencies of vitamin B12 and choline, which help to control homocysteine.
Some followers of the Paleo who mainly eat muscle meat and ignore the "nose-to-tail" philosophy, can therefore also be subject to a low consumption of glycine, something that in the Paleolithic did not happen because the whole animal was consumed.
"Primitive Collagen" is UNIQUE!
In fact, it has been formulated together with other substances to further amplify the fire power of its numerous benefits, a series of synergistic molecules that create a unique product, completely different from all the other collagen-based products that exist on the market.
So in addition to top quality hydrolyzed collagen, "Primitive Collagen" also contains:
- C vitamin
Vitamin C (ascorbic acid) is fundamental for the synthesis of hyaluronic acid. Hyaluronic acid has been advertised to accelerate recovery times and relieve painful joints.
Without adequate levels of vitamin C, your body will not get the maximum benefit from foods containing hyaluronic acid.
A study suggests that hyaluronic acid can help improve collagen production in the human body.
Hyaluronic acid is found naturally in the body, but decreases with age, so eating foods / supplements rich in vitamin C and amino acids can increase the levels of hyaluronic acid and collagen in the body since both are important for the skin.
Vitamin C is therefore fundamental precisely for the production of collagen and therefore in "Collagen Primitive" as many as 900 mg of pure ascorbic acid have been inserted, which represent as much as 1125% of VNR (Reference Nutrient Values).
Zinc is a nutrient that plays many vital roles in your body and for this reason, it is necessary to obtain a constant supply through the diet and / or supplements.
Zinc is required for numerous processes in your body, including (1):
Growth and development
Zinc is the second most abundant mineral in your body - after iron - and is present in every cell (2).
Zinc is necessary for the activity of over 300 enzymes that help metabolism, digestion, nerve function and many other processes (3).
Furthermore, it is essential for the development and function of immune cells (4).
This mineral is also essential for skin health, DNA synthesis and protein production (5).
Furthermore, the growth and development of the body depend on zinc for its role in growth and cell division (6).
Zinc is also necessary for your senses. Since one of the crucial enzymes for taste and smell is dependent on this nutrient, a deficiency of zinc can reduce the ability to taste or smell (7).
Zinc is essential for cell growth and division, immune function, enzymatic reactions, DNA synthesis and protein production.
Research shows that zinc has numerous health benefits because it helps keep your immune system strong.
Because it is necessary for immune cell function and cell signaling, a deficiency can lead to a weakened immune response.
Zinc supplements stimulate particular immune cells and reduce oxidative stress.
For example, a review of seven studies showed that 80-92 mg of zinc a day can reduce the length of the common cold by up to 33% (8).
Furthermore, zinc supplements significantly reduce the risk of infections and promote the immune response in the elderly (9).
Zinc is commonly used in hospitals as a treatment for burns, some ulcers and other skin lesions (10).
Since this mineral plays a fundamental role in collagen synthesis, in immune function and in the inflammatory response, it is necessary for proper healing.
In fact, your skin contains a relatively high amount - about 5% - of your body's zinc content (11).
While a zinc deficiency can slow down wound healing, zinc supplementation can speed recovery in people with wounds.
For example, in a 12-week study in 60 people with diabetic foot ulcers, those treated with 200 mg of zinc per day showed significant reductions in ulcer size compared to a placebo group (12).
Zinc can significantly reduce the risk of age-related diseases, such as pneumonia, infection and age-related macular degeneration (AMD).
Zinc can relieve oxidative stress and improve the immune response by increasing the activity of T cells and natural killer cells, which help protect the body from infections (13).
The elderly who supplement zinc have improved their response to influenza vaccination, reduced the risk of pneumonia and increased mental performance (14, 15, 16).
In fact, one study has determined that 45 mg of zinc a day can reduce the infection rate in the elderly by almost 66% (17).
In addition, in a large study of over 4,200 people, taking daily antioxidant supplements - vitamin E, vitamin C and beta-carotene - plus 80 mg of zinc reduced vision loss and significantly reduced the risk of advanced AMD (18).
Acne is a very common skin disease that is estimated to affect up to 9.4% of the global population (19).
Acne is driven by the obstruction of glands, bacteria and oil-producing inflammation (20).
Studies suggest that both topical and oral zinc treatments can effectively treat acne by reducing inflammation, inhibiting the growth of P. acnes bacteria and suppressing oily gland activity (21).
People with acne tend to have lower levels of zinc. Therefore, supplements can help reduce symptoms (22).
Zinc reduces oxidative stress and reduces the levels of some inflammatory proteins in the body (23). Oxidative stress leads to chronic inflammation, a factor that contributes to a wide range of chronic diseases, such as heart disease, cancer and mental decline (24).
In a study of 40 older adults, those taking 45 mg of zinc per day experienced a greater reduction in inflammatory markers than in a placebo group (25).
Zinc can therefore effectively reduce inflammation, increase immune health, reduce the risk of age-related diseases, accelerate wound healing and improve acne symptoms.
Although severe zinc deficiency is rare, it can occur in people with rare genetic mutations, breastfed babies whose mothers do not have enough zinc, people with alcohol dependencies and anyone who takes certain immunosuppressive drugs.
Symptoms of severe zinc deficiency include reduced growth and development, delayed sexual maturity, rash, chronic diarrhea, wound healing and behavioral problems (26).
Milder forms of zinc deficiency are more common, especially in children in developing countries where diets are often free of important nutrients.
An estimated 2 billion people worldwide are deficient in zinc due to inadequate dietary intake (27).
Because zinc deficiency damages the immune system, increasing the chances of infection, zinc deficiency is believed to cause over 450,000 deaths in children under the age of 5 each year (28).
Among those at risk of zinc deficiency (29):
People with gastrointestinal diseases such as Crohn's disease
Vegetarians and vegans
Pregnant and nursing women
Older children who are exclusively breastfed
People with sickle cell disease
People who are malnourished, including those with anorexia or bulimia
People with chronic kidney disease
Those who abuse alcohol
Symptoms of mild zinc deficiency include diarrhea, decreased immunity, hair loss, decreased appetite, mood disorders, dry skin, fertility problems and wound healing (30).
Zinc deficiency is difficult to detect using laboratory tests due to the body's strict control of zinc levels. Therefore, you may still be lacking even if the tests indicate normal levels.
For this reason and in particular for his great work on the production of collagen, in "Collagen Primitive" 6 mg of Zinc have been inserted, which represent 60% of the VNR (Reference Nutrient Values), which indicate the quantity of vitamins and minerals that a person should take to meet the minimum daily requirement.
There are so many collagen products around but only "Collagen Primitive" contains Ornithine, which, by amplifying the overall power of the product, makes it absolutely unique.
In fact, a scientific study has compared two groups of people to whom the initial degree of:
Transepidermal water loss (TEWL)
One group was given a drink containing Collagen and Ornithine, while to the other group a placebo drink, that is without active ingredients.
Obviously, neither group knew exactly what they were taking, whether collagen + ornithine or nothing, in order to increase the effectiveness of the experiment.
After 2 months they re-measured the values.
Skin elasticity and transepidermal water loss were significantly improved in the group that received collagen + ornintine compared to the placebo group.
Furthermore, only the collagen + ornithine group showed an increase in plasma IGF-1 levels after 8 weeks of integration compared to baseline.
The IGF1 hormone takes its name from the English terms insulin like growth factor, or similar insulin growth factors.
It is produced by the liver and is one of the mediators of the growth hormone called GH, and therefore serves to stimulate the development of certain tissues in the human body, such as bones, muscles, skin and brain.
It also controls insulin resistance, making it more difficult to contract diabetes.
These results have also been confirmed by another study in which it has been proven that ornithine stimulates polyamine concentrations that are known to increase the synthesis of certain proteins and improve the epidermal barrier function of the skin.
This research shows that oral administration of ornithine significantly affects the chemical composition of the skin through increases in both amino acids and polyamines after a short period of time.
Ultimately "Collagen Primitive" is currently the only formulation in the world that contains Hydrolyzed Collagen boosted with:
Ornithine + Zinc + vitamin
Packaging: 300 grams of hydrolyzed Collagen (Powder)
Do not exceed the recommended daily dose. Dietary supplements are not intended as a substitute for a varied and balanced diet. Keep out of reach of children under three years. Do not use in pregnancy and in children or for prolonged periods without consulting a doctor. Store in a dry place away from heat sources. Close the package after use.
Collagen: The Fibrous Proteins of the Matrix at https://www.ncbi.nlm.nih.gov/books/NBK21582/
The Amino Acid Composition of Mammalian Collagen and Gelatin à https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1215839/pdf/biochemj00862-0065.pdf
The effect of oral collagen peptide supplementation on skin moisture and the dermal collagen network: evidence from an ex vivo model and randomized, placebo-controlled clinical trials https://onlinelibrary.wiley.com/doi/full/10.1111/jocd.12174
Oral Ingestion of Collagen Hydrolysate Leads to the Transportation of Highly Concentrated Gly-Pro and its Hydrolyzed Form of Pro-hypyplasty into the Bloodstream and Skin à https://www.ncbi.nlm.nih.gov/pubmed/28244315
The effect of pacific cod (Gadus macrocephalus) skin gelatin polypeptides on UV radiation-induced skin photoaging in ICR mice à https://www.sciencedirect.com/science/article/pii/S0308814609000387
Effect of daily gelatin ingestion on human scalp hair à https://www.researchgate.net/publication/279548216_Effect_of_daily_gelatin_ingestion_on_human_scalp_hair
effect of gelatin-cystine ano serenoa repens extract on free radicals level and hair growth at http://iscd.it/files/EFFECT-OF-GELATIN-CYSTINE-ANO-SERENOA-REPENS-EXTRACT-ON-FREE-RADICALS-LEVEL -and-HAIR-GROWTH.pdf
Glycine ingestion improves subject sleep quality in human volunteers, correlating with polysomnographic changes à https://onlinelibrary.wiley.com/doi/full/10.1111/j.1479-8425.2007.00262.x
Subjective effects of glycine ingestion before bedtime on sleep quality at https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1479-8425.2006.00193.x
Glycine neurotransmitter transporters: an update à https://www.ncbi.nlm.nih.gov/pubmed/11396606
Role of collagen hydrolysis in bone and joint disease à https://www.ncbi.nlm.nih.gov/pubmed/11071580
Collagen hydrolysate for the treatment of osteoarthritis and other joint disorders: a review of the literature à https://www.ncbi.nlm.nih.gov/pubmed/17076983
24-Week study on collagen hydrolysate as a dietary supplement in athletes with activity-related joint pain https://www.ncbi.nlm.nih.gov/pubmed/18416885
Effect of amino acids lysine and arginine on healing fractures in rabbits: A radiological and histomorphological analysis à https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2762560/
Protection of gastric mucosal integrity by gelatin and simple proline-containing peptides à https://www.pathophysiologyjournal.com/article/S0928-4680(00)00045-6/fulltext
Possible Links between Intestinal Permeablity and Food Processing: A Potential Therapeutic Niche for Glutamine à https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2898551/
Eight health benefits of gelatin à https://www.medicalnewstoday.com/articles/319124.php
Glycine metabolism in skeletal muscle: implications for metabolic homeostasis à https://www.ncbi.nlm.nih.gov/pubmed/28375879
Dietary meat and protection against sarcopenia à https://www.ncbi.nlm.nih.gov/pubmed/29941158
Oral ingestion of a hydrolyzed gelatin meal in subjects with normal weight and in obese patients: Postprandial effect on circulating gut peptides, glucose and insulin à https://www.ncbi.nlm.nih.gov/pubmed/18319637
Glycine treatment decreases proinflammatory cytokines and increases interferon-gamma in patients with type 2 diabetes à https://www.ncbi.nlm.nih.gov/pubmed/18852529
Beneficial effects of glycine (bioglycin) on memory and attention in young and middle-aged adults à https://www.ncbi.nlm.nih.gov/pubmed/10587285
Nutritional therapies for mental disorders à https://nutritionj.biomedcentral.com/articles/10.1186/1475-2891-7-2
Effect of gelatins on human cancer cells in vitro à https://www.ncbi.nlm.nih.gov/pubmed/12804040
25. Vitamin B-12 and homocysteine status among vegetarians: a global perspective https://academic.oup.com/ajcn/article/89/5/1693S/4596963
Iron and Zinc Nutrition in the Economically-Developed World: A Review à https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3775249/
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Zinc in Human Health: Effect of Zinc on Immune Cells à https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2277319/
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Effect of Zinc Supplementation on Growth Outcomes in Children under 5 Years of Age à https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5872795/
A Randomized, Placebo Controlled Trial of Oral Zinc for Chemotherapy-Related Taste and Smell Disorders à https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4042409/
Zinc lozenges and the common cold: a meta-analysis comparing zinc acetate and zinc gluconate, and the role of zinc dosage at https://www.ncbi.nlm.nih.gov/pubmed/28515951
The immune system and the impact of zinc during aging - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2702361/
Pressure ulcers: Current understanding and newer modalities of treatment at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4413488/
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The effects of zinc supplementation on wound healing and metabolic status in diabetic foot ulcers: A randomized, double-blind, placebo-controlled trial à https://www.ncbi.nlm.nih.gov/pubmed/28395131
The immune system and the impact of zinc during aging at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2702361/
Zinc in the elderly: effects of zinc supplementation on psychological dimensions in the dependence of IL-6 -174 polymorphism: a Zincage study à https://www.ncbi.nlm.nih.gov/pubmed/18341424
Low zinc status: a new risk factor for pneumonia in the elderly? à https://www.ncbi.nlm.nih.gov/pubmed/20041998
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A global perspective on the epidemiology of acne à https://www.ncbi.nlm.nih.gov/pubmed/25597339
The role of zinc in the treatment of acne: A Review of the Literature
Innovative uses for zinc in dermatology at https://www.ncbi.nlm.nih.gov/pubmed/20510767
Correlation between Severity and Type of Acne Lesions with Serum Zinc Levels in Patients with Acne Vulgaris à https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4135093/
Cytokines in the Pathogenesis of Rheumatoid Arthritis and Collagen-Induced Arthritis à https://www.ncbi.nlm.nih.gov/books/NBK6288/
Chronic Inflammation à https://www.ncbi.nlm.nih.gov/books/NBK493173/
Zinc decreases C-reactive protein, lipid peroxidation, and inflammatory cytokines in elderly subjects: a potential implication of zinc as an atheroprotective agent1,2,3 à https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2869512 /
Enteropathic Acrodermatitis - A Case Report à https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4902399/
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Foods highest in Zinc à https://nutritiondata.self.com/foods-000124000000000000000-3w.html?
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Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc à https://www.ncbi.nlm.nih.gov/books / NBK222317 /
Mar Drugs. 2018 Dec 3; 16 (12). pii: E482. doi: 10.3390 / md16120482. Effects of Composite Supplement Containing Collagen Peptide and Ornithine on Skin Conditions and Plasma IGF-1 Levels-A Randomized, Double-Blind, Placebo-Controlled Trial. Ito N1, Seki S2, Ueda F3. à https://www.mdpi.com/1660-3397/16/12/482
Biochem Biophys Res Commun. 2019 May 14; 512 (4): 712-715. doi: 10.1016 / j.bbrc.2019.03.147. Epub 2019 Mar 27.Oral administration of l-ornithine increases the content of both collagen constituting amino acids and polyamines in mouse skin.Harada D1, Nagamachi S1, Aso K1, Ikeda K1, Takahashi Y2, Furuse M3. à https://www.ncbi.nlm.nih.gov/pubmed/30926170